Commentary by G. Edward Griffin
VIDEO: I have been taking Cardio Miracle since 2014. Based on my experience, I am convinced it yields greater benefit for more people – and costs less to get that benefit – than anything before it.
[If you would rather not listen to my boring explanation, you can read a condensed, version stating with INTRODUCING CARDIO MIRACLE, below. ]
|INTRODUCING CARDIO MIRACLE In 2014, the people who produce Cardio Miracle began incorporating these discoveries into a new formulation that follows both nitric-oxide pathways – and they added several high-potency anti-oxidants to enhance the second path. This is not a mix of patented chemicals claiming to contain “natural flavors” (which often means more chemicals). When you read the label, shown in the FAQ section at the end of this review, you will see that Cardio Miracle is dominantly composed of dried, non-GMO foods. The powders are derived from real fruits and vegetables and prepared with the absolute minimum of processing so as to retain nutrients. The remaining ingredients are not just vitamins, minerals, and enzymes, but also include natural substances that aid the body’s production of nitric oxide at the cellular level. In 1915, Jonathan Stamler, a professor of medicine at Case Western Reserve University School of Medicine discovered that respiration is a three-gas system involving, not just oxygen and carbon dioxide, but also nitric oxide, which controls the ability of blood vessels to expand, when needed, to increase blood flow. Without this ability to expand blood vessels on demand, such as during physical exertion or emotional stress, the delivery of oxygen will be inadequate and can lead to heart failure or stroke. See “Molecular and functional basis established for nitric oxide joining oxygen and carbon dioxide in respiratory cycle,” The Daily, Case Western Reserve University, 2015 April 30, http://thedaily.case.edu/molecular-and-functional-basis-established-for-nitric-oxide-joining-oxygen-and-carbon-dioxide-in-respiratory-cycle|
THE MANY EFFECTS OF CARDIO MIRACLE Although my initial interest in this product was its ability to lower blood pressure, it soon became apparent from the testimonials we were receiving that there are many other benefits as well – and some of them are big. The following unsolicited letters from users tell the story.
HIGH BLOOD PRESSURE
CONGESTIVE HEART FAILURE (insufficient blood flow from heart)
NEUROPATHY (numbness, usually in feet and legs)
|I became interested in Cardio Miracle because it helped my wife with her neuropathy. I decided I might as well take it along with her since it couldn’t do me any harm. Then I noticed that the white biofilm coating I had on my tongue most of my life unexplainably went away – and improved my breath freshness. That made me happy. Since I am a dentist, I’m sure it made my patients happy also. ~~ Gene Duffin, DDS [See video]|
|Following my surgery, the pain was unbearable, and the loss of sensation in my feet and legs plus the loss of muscular control made it almost impossible to walk. Drugs didn’t help, and the doctors were baffled. Then I tried Cardio Miracle and could hardly believe that my pain and neuropathy quickly vanished. |
~~ Aminika, Dallas/Fort Worth [See video]
COPD (Chronic Obstructive Pulmonary Disease)
PERIODONTITIS (receding or bleeding gums) and ROOT CANAL
When I read Ray Potter’s testimonial, I wondered if this could be the result of something other than Cardio Miracle, such as a change in diet or reduction of stress. When I looked to see if there was any scientific support for thinking nitric oxide might be responsible, I found that researchers at State University in Rio de Janeiro, Brazil, studied that very issue and said there was, indeed, scientific support for the theory behind it. (1) It didn’t take long for me to schedule a dental appointment to get a current assessment of my own periodontitis to see if Cardio Miracle made a difference. Like Ray Potter, I was uneasy that there would be no positive effect but, when the results were compared to my previous exam, the improvement was nothing less than spectacular.
My previous exam showed 69 pockets that were deep enough to be classified as affected by periodontitis. This time, there were only 24. That’s an amazing improvement of 65%. My hygienist, who usually admonishes me to increase the frequency of my teeth cleaning, studied the charts for a moment and said: ‘Well, I guess this takes the steam out of my argument.’
Eleven months later (on 2016 April 12), when I returned for another cleaning, the pocket count had further declined to 17. That’s a 75% improvement from what is was before taking Cardio Miracle. This time, the hygienist asked how to obtain the product. ~~ G. Edward Griffin, Los Angeles (1) “Nitric oxide and oral diseases: can we talk about it?” ResearchGate.net.
|Cardio Miracle brought down my blood pressure so I no longer need Statin drugs. It brought my triglyceride levels into normal range and also boosted my Vitamin-D levels by more than 50%. As a dentist, I am particularly impressed by its ability to virtually eliminate periodontal disease. I now recommend it to all my patients, most of whom report marked improvement within 60 days. [See video] ~~ Tom Worcester, DDS, Member of the Crown Council, Florida|
|Severe pain in my jaw sent me to my dentist who said I was in immediate need of a root canal on an infected tooth. I am skeptical about the value of root canals, so I wanted to find another solution other than tooth extraction. I knew that Cardio Miracle was helping people with gum disease, so I decided to see if it would help my deeply infected tooth. Swishing the formula around the tooth for a minute before swallowing produced a sensation of healing. After just a few days, the pain was gone. My tooth seems to be fine now. [See video] “ ~~ Arlaine Austin|
OBESITY (For information on how Cardio Miracle combats obesity, see the Q&A section at the bottom of this page.)
|90 days after starting Cardio Miracle. I’ve lost 23 pounds, because I have more energy to exercise. I no longer take blood-pressure medication, and my blood pressure reading this morning was 120/79. ~~ Greg Anderson – Salt Lake City, Utah|
|As a Harvard-trained, board-certified emergency physician, I can say that Cardio Miracle truly is a miracle. It brought my blood pressure down from 145/95 to 120/78 with no prescription medications, and I’m growing more hair. I strongly recommend the product.” ~~ Josh Helman, M.D.* “I am a licensed medical professional and therapist. For years, I endured chronic nerve pain and never could find something that controlled pain without side effects. Now, Cardio Miracle removes my pain in 15 to 30 minutes with no side effects. Two scoops of Cardio Miracle works better than two IBuprofen. ~~ Heidi Crockett* * See video here.|
|If I could take one supplement and one supplement only, it would be a nitric oxide booster. ~~ Stephen Ashcraft, a physiologist in Nashville, Tennessee|
|For me, Cardio Miracle has been the perfect gift. It has done more for me in one year that medicine has done in the previous forty. The neuropathy in my fingers and toes is gone. I sleep better. I’m healthier, stronger, have more energy. Cardio Miracle gives me a sense of health security that I don’t get from Big Pharma or establishment medicine. ~~ Ken Sheldon [See video]|
|“Nitric-Oxide therapy has affected my wife, Diane significantly. Her actual age 68 was a far cry from the test results (heart age 92) back in May 2011. After 8 months her heart age is now 55! Blood pressure went from 168/92 to 121/76. In addition she was able to have carpel tunnel surgery cancelled because the symptoms went away. Diane had a full knee replacement in 2013 and another one in 2014. Her surgeon and physical therapist told us she recovered twice as fast as anyone they had seen in 25 years!” ~~ Robert Haunschild. (no photo available at present)|
|The method by which these fruits and vegetables are converted into powder is amazing. Heating or freeze-drying food to create dry powders destroys much of the vitamin and enzyme content. It’s a terrible loss of nutrition. However, the powders used in Tropical Abundance are created from a process called Infidri, which uses light waves to resonate with water molecules and drive them out of food without damaging nutritional content or flavor. It’s an impressive technology. (See www.powderpure.com) All powdered foods in this process are non GMO.|
|Cardio Miracle contains: Beet Root powder, Carrot powder, Coconut powder, Beet Root crystals, Pine Bark extract, Tumeric, Grape-Seed extract, Watermelon extract, Astralagas root, Panex Ginseng, Hawthorne Berry extract, Resveratrol, Astragin, Astraxanthin, L-Arginine, L-Citrulline, Ornithine, D-Ribose, Alpha Lipoic Acid, trace minerals, sea salt, CoQ10, Pycnogenol, Selenium, Magnesium, Zinc, and a broad spectrum of Vitamins, including D3 and K2. These often are absent even from premium brands of multi-vitamin supplements. The full label is shown in the Frequently-Asked Questions section.|
|Frequently Asked Questions|
|What are the Cardio Miracle ingredients? Here is the product label for the sugar-free (Stevia) version:|
Why isn’t nitric oxide listed on the product list of ingredients?
We apologize for not making this more clear on the product page, but Cardio Miracle does not contain nitric oxide, which is a gas. Instead, it contains the substances the body uses to produce nitric oxide right inside the cells.
Is there a danger of Cardio Miracle overdose leading to fatally low blood pressure?
There is no evidence of that after extensive use, but there is a theoretical concern for high-performance athletes. See “Potentially fatal new trend in performance enhancement: a cautionary note on nitrite,” by Andrea Ptroczi and Decian P. Naughton, Journal of the International Society of Sports Nutrition, 2010, 7:25.
How do you know that the loss of neuropathy is not merely the placebo effect?
It is impossible for patients to experience complete loss of advanced neuropathy based on the placebo effect. An excellent reference regarding the theoretical action of nitric oxide on neurons is: Nitric Oxide and Its Role in Health and Diabetes, by Thomas Burke, Ph.D. with special focus on Parts 5 and 8.
Is there a reliable reference for a technical description of the Nitrate/Nitrite pathway to nitric oxide?
There are numerous studies on this topic available online. A good choice would be: “The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics,” by Jon O. Lundburg, Eddie Weitzberg, & Mark T. Gladwin, Nature Reviews Drug Discovery 7,156-167 (Feb. 2008).
If L-arginine is the beginning of the chemical pathway to nitric oxide, why does Cardio Miracle include Citrulline? What is Citrulline, anyway and what’s all the fuss about the ratio between Arginine and Citrulline?
Great question for those who really want to understand how this product works and what sets it apart from others. Citrulline is (missing text)
Are there negative side effects from consuming sodium nitrite?
There have been studies showing a relationship between high levels of dietary sodium nitrite and cancer. It is believed that this process is initiated by abnormal oxidative stress. At low to moderate levels, such as are found in Cardio Miracle, we are not aware of any such connection. It is common for food factors to be beneficial or even essential in small quantities but harmful in large quantities. Sodium nitrite is an important part of Cardio Miracle because it is a precursor to the body’s production of nitric oxide, which is essential for life. However, to be on the side of caution, the manufacturer has added substantial levels of potent anti-oxidants to eliminate any oxidative stress that might be present. See “The Effects of Sodium Nitrite,” by Jan Annigan, reviewed by Brenda Spriggs, MD, MPH, MBA, Healthline, Aug. 16, 2013.
Does Cardio Miracle need to be refrigerated to keep its freshness?
No. It should be treated like a dried food, which most of it is. After opening, it will last for several years with no problem as long as it is stored in a cool, dry location. If atmospheric moisture causes clumping, that will not adversely effect the product’s effectiveness in any way. Clumps are easily broken up, and the product will quickly dissolve in water or juice as before.
Are there any special discounts on this product for Reality Zone customers?
Due to improved product ingredients and inflation, the increased cost of Cardio Miracle has required that all special discounts for special groups be ended. Discounts may be issued in the future on special occasions but will have specific ending dates.
For cardiovascular benefit, why not just take Viagra as it’s cheaper and probably more effective?
The answer to this is provided by Stephen Ashcraft, a physiologist in Nashville, Tennessee. [[email protected]] “To understand how Viagra works, we must first understand what physiological response causes an erection. The body releases Nitric Oxide (NO) when we are sexual stimulated. This NO release comes from nerve endings and endothelial cells in the corpus cavernosum of the penis and clitoris. An enzyme then converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). cGMP then causes the smooth muscle of the vessels in the penis, or clitoris, to relax, which then allows for a greater inflow of blood which then leads to an erection. cGMP is then hydrolyzed back to the inactive GMP by phosphodiesteras type 5, also known as PDE5. “We know that most Men who suffer from erectile dysfunction do not produce enough NO. This is why we can say that erectile dysfunction is one of the earliest visible responses to cardio vascular disease. Because of low NO production in these men, the small amount of cGMP they produce is broken down at the same rate and therefore doesn’t have the time required, to accumulate, and cause a prolonged vasodilatation effect, the erection. “Sildenafil (Viagra) is a potent and highly selective inhibitor of PDE5. Sildenafil (Viagra) works by inhibiting the enzyme PDE5 (phosphodiesteras). This means that cGMP is not hydrolyzed as fast and this allows the vessel smooth muscle to relax. 1. Viagra does not increase NO production, thus one would not receive the numerous benefits, to the cardiovascular system, of NO. 2. Viagra has numerous negative side effects. 3. PDE5 function is specific to the penis and clitoris. 4. The response is short lived and not recommended for using multiple doses per day. “Cardio Miracle provides a consistent elevation of NO, thus causing the vascular system to function as it is suppose to, dilating and constricting according to cardiac output and increased stroke volume. Neither Viagra nor its competitor drugs provide this response. Erectile Dysfunction has been shown in research to diminish with greater NO production.”
A respected alternative-medicine doctor has said in his newsletter that supplemental L-arginine is a poor source for increasing nitric oxide, and possibly does not work at all. If this is true, why is it in Cardio Miracle?
Again, we will defer to Stephen Ashcraft [[email protected]] for the answer:
“There are several, obvious, issues with this article. First, [the doctor] is selling another product, one he claims works better for NO production than L-arginine. Rather than argue the point, I would simply refer him, or any other inquisitive person, to the hundreds if not thousands of clinical trials proving the effectiveness of L-arginine as a precursor and producer of NO. Furthermore, I would remind him, and others, the 1998 Noble Prize Winner, for medicine, Dr. Louis Ignarro, won the Noble Prize for discovering NO. Dr. Ignarro went on, in his book “No More Heart Disease,” to explain in great detail the benefits of L- arginine.
“Second, the [doctor’s] article is correct in that oral L-arginine does convert to urea. It also converts to NO, ornithine, and agmatine. … Many of the health benefits, from L-arginine, can be attributed to the fact that some of the L-arginine converts to urea. Urea has many health benefits. It supports protein synthesis, thus its importance for patients suffering from kidney failure, kidney infections, and for athletes who are wanting to gain greater muscle mass. Urea is also the best diuretic and has proven helpful with brain tumors, strokes, meningitis and other inflammations of the brain and spinal cord. One report cites the case of a massive brain tumor reappearing 3 months after surgical removal of another brain tumor. The patient received 256ml of 30% urea. After 2 hours the tumor had completely disappeared. Urea is also very beneficial in wound healing, even infected wounds, burns and ulcerating tumors. Urea is one of the main reasons L-arginine, converting to NO, is such a powerful recovery agent. Urea greatly reduces exercise recovery time by removing ammonia, a by-product of lactic acid, which occurs from repetitive muscular contractions. So, while it is certainly true that some of the L-arginine converts to urea, it is also a good thing.
“Also, it is true that L-arginine can be very difficult to assimilate. Studies have shown that our bodies utilize less than 50% of the L-arginine we consume. This means that you can’t digest and use L-arginine efficiently. It is for this reason, that hospitals, and many researchers use intravenous arginine injection instead of oral doses. The Cardio Miracle solution to this problem is a different form of arginine called, L-arginine AAKG (alpha-ketoglutarate). AAKG has been shown to have a 90% utilization rate. Also, by adding the amino acid, L-citrulline, and other active NO boosters, you can greatly enhance the effectiveness of L-arginine conversion in the NOS pathway. Furthermore, the pharmaceutical grade AAKG form of L-arginine gives the endothelium support and vaso-relaxation properties of arginine, plus greater arginine stability, bioavailability, and absorption. If that’s not enough, the AAKG serves as a transport medium for arginine, thus making it available at the cellular level for optimal synthesis. AAKG will also improve endogenous production of glutamine and glutamic acid, both of which are important for muscle growth.
“Another noteworthy fact of Cardio Miracle is the dual-pathway of delivery. The two primary ways our bodies generate and deliver NO are: (1) the enzymatic process that oxidizes a nitrogen atom in the amino acid, arginine, to nitric oxide. This process is known as the arginine-nitric oxide pathway. Arginine is converted to NO by the endothelium. L-citrulline, also used in the Cardio Miracle formula, is another amino acid and can also be converted into NO by means of the same pathway. (2) The second pathway is a non-enzymatic process where nitrites and nitrates, which are naturally occurring, are converted to NO either by bacteria in the intestine and mouth, or by naturally occurring antioxidants. Some fruits and roots are converted into NO via this same pathway. By taking advantage of both pathways, and adding additional NO boosters, Cardio Miracle extends the active life of NO, in the system.
“NO can oxidize and become a free radical. Cardio Miracle is loaded with some of the most powerful antioxidants known that lower homocysteine levels and inhibit the oxidation process. Another way of eliminating any concern of the free-radical issue is the NO loop. By combining other key NO precursors a loop is created, thereby protecting the NO from becoming a free radical and greatly extending the life of NO.
“Most NO boosters, on the market, rely on L-arginine as their primary source for NO. A few, and I mean a very few, will use some L-citrulline; and even fewer will use AAKG. As we’ve already mentioned, there are a number of sources of NO production. NOS occurs through several different pathways, thus Cardio Miracle, a product that actually works, uses multiple pathways of delivery. Because Cardio Miracle contains multiple sources of NO precursors and multiple pathways of delivery, it contains a lower dose of L-arginine and also greatly enhance the health benefits of NO.”
What are endothelial progenitor cells, and what do they have to do with Cardio Miracle?
Endothelial refers to a layer of cells that line the inner walls of the circulatory system, everything from the heart to the smallest capillaries. Their function is to pass nutrients from the bloodstream into the organs ‒ and pass waste products in the opposite direction where they are carried to the liver and kidneys for disposal. Since all functions of life depend on that process, healthy endothelial cells are essential for health and youth. The bad news is that endothelial cells have a life span of only a few years (even shorter when exposed to toxins from drugs, processed food, and contaminated air). The good news is that the body is able to replace those dying endothelial cells with new ones. That’s where the word progenitor comes into play. It refers to a stem cell that is programmed by its DNA to morph into a specialized cell that can replace an aging or damaged cell. Therefore, endothelia progenitor cells (EPCs) gradually become new endothelia cells. The bad news, however, is that the body’s ability to produce EPCs diminishes with age, which is a major cause of declining health and vigor as we grow older. But the final good news is that researchers recently have discovered a way, not only to increase the body’s production of EPCs, which occurs in bone marrow, but to send them to precise locations in the cardio-vascular system that need them the most ‒ and it does this regardless of age. (See Nitric oxide differentially regulates proliferation and mobilization of endothelial progenitor cells but not of hematopoietic stem cells. Ozüyaman B1, Ebner P, Niesler U, Ziemann J, Kleinbongard P, Jax T, Gödecke A, Kelm M, Kalka, http://th.schattauer.de/en/contents/archive/issue/769/manuscript/4265.html) Cardio Miracle stimulates the body to increase its own, natural production of nitric oxide ‒ and that is the substance that stimulates the production of EPCs.
How does Cardio Miracle combat obesity?
Most of the benefits of Cardio Miracle can be understood as the result of improved circulation and oxygenation, but combating obesity is related to a biological process called mitochondrial biogenesis. Don’t be intimidated by the words. They simply mean the body’s production of a component of all cells (the mitochondria) that converts nutrients derived from food into energy. Mitochondrial biogenesis also is dependent on oxygenation, but its function is related to the accumulation of body fat. An efficient mitochondria readily converts nutrients derived from food into energy, and only excess food consumption is left over for fat. If the mitochondria are not efficient, the conversion to energy will be impaired, a condition called low metabolism. This causes low energy levels ‒ manifested as weakness and fatigue ‒ and increased fat formation. Many things can reduce the function of mitochondria, everything from enzymatic dysfunction to toxins to aging. Therefore, anything that supports the maintenance of healthy mitochondria will combat obesity ‒ especially if related to low metabolism. The effect of nitric oxide on diabetes was the topic of a 2014 study by Brian Sansbury and Bradford Hill.(1) They found that nitric oxide does help control diabetes, but it does so because of how it combats obesity:
● It reduces insulin resistance.
● It regulates appetite.
● It supports the production and efficiency of mitochondria.
The researchers stated: “Overall, the collective data suggest that L-arginine, and by inference, NO [nitric oxide], has the capacity to reduce fat mass by increasing mitochondrial biogenesis, regulating brown adipose tissue signaling, and increasing the expression of genes that promote oxidation of energy substrates.” In laymen’s terms, that means: Nitric Oxide (which is produced by the body in response to the dietary presence of an amino acid called L-Arginine) reduces fat by decreasing appetite and increasing the body’s ability to convert food into energy. (1) “Regulation of Obesity and Insulin Resistance by Nitric Oxide”, by Brian E. Sansbury1 and Bradford G. Hill1, Science Direct, Free Radical Biology and Medicine, Vol 73, August 2014. pp. 382-399. http://www.sciencedirect.com/science/article/pii/S0891584914002329 Also: also: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002/ This paper also contains an excellent overview of many other health effects of ample nitric-oxide.
SHORT VERSION OF MR. GRIFFIN’S EXPERIENCE WITH CARDIO MIRACLE
To my amazement, great results were measurable immediately. My blood pressure, which was 170 over 94 on the day I started the trial, began dropping by about 15 points per month and didn’t stop until it hit numbers I had not seen since I was in my 20s. Currently, it is running at about 120 over 72.
UNEXPECTED BONUS BENEFITS